Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
ML329
CAS: 19992-50-8
Molecular Formula: C16H12N2O4S
Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]- - Names and Identifiers
| Name | ML329 |
| Synonyms | ML329 ML 329 4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]- |
| CAS | 19992-50-8 |
| EINECS | 604-604-1 |
Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]- - Physico-chemical Properties
| Molecular Formula | C16H12N2O4S |
| Molar Mass | 328.34 |
| Solubility | DMSO : ≥ 31 mg/mL (94.41 mM) |
| Storage Condition | 2-8°C(protect from light) |
| Use | ML329 is a microocular malformation related transcription factor (MITF) inhibitor. ML329 inhibits TRPM-1 promoter activity with an IC50 value of 1.2 μM. |
| Target | TRPM-1; MITF |
| In vitro study | ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression. |
Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]- - Reference
| Reference Show more | 1. Faloon PW, et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): N/AtioN/Al Center for Biotechnology Information (US); 2010-2012 Dec 13. |
Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.046 ml | 15.228 ml | 30.456 ml |
| 5 mM | 0.609 ml | 3.046 ml | 6.091 ml |
| 10 mM | 0.305 ml | 1.523 ml | 3.046 ml |
| 5 mM | 0.061 ml | 0.305 ml | 0.609 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: ML329 Visit Supplier Webpage Request for quotationCAS: 19992-50-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: ML329 Visit Supplier Webpage Request for quotationCAS: 19992-50-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ML329 Visit Supplier Webpage Request for quotationCAS: 19992-50-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: ML329 Visit Supplier Webpage Request for quotationCAS: 19992-50-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
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